Published by: NISCAIR (CSIR)
Indian Journal of Chemistry (Section B) is published by the National Institute of Science Communication and Information Resources (NISCAIR)-CSIR, New Delhi. This journal publishes articles in Organic and Medicinal Chemistry. It includes full length papers, notes and communications and short reviews. The monthly issues covers articles in organic reaction mechanism, theoretical organic chemistry, structure-activity relationships, medicinal chemistry, synthesis of chiral compounds, bio-organic chemistry, enzymes in organic synthesis, reagents in organic synthesis, heterocyclic compounds, phytochemistry (natural products), amino acids, peptides and proteins, spectroscopy in characterization of organic compounds, chemoenzymatic and enantioselective synthesis of organic compounds, synthesis of fullerenes, metal-catalyzed asymmetric reactions, bioactive plant products and combinatorial chemistry.
Dr. P Paravatharajan
ISSN No. : 0376-4699
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Synthesis, characterization and antimicrobial activity of ethyl 2-(3-formyl-4-((4-hydroxy-2-oxo-2H-chromen-3-yl)-alkoxy-)phenyl)-4-methylthiazole-5-carboxylate derivatives
Title: Synthesis, characterization and antimicrobial activity of ethyl 2-(3-formyl-4-((4-hydroxy-2-oxo-2H-chromen-3-yl)-alkoxy-)phenyl)-4-methylthiazole-5-carboxylate derivatives
Authors: Malik, G M; Naik, Chirag G
Abstract: During the present study, a number of
substituted thiazole derivatives
have been synthesized by the reaction of 4-hydrox-ybezene-1-carbothiomide and
ethyl-2-chloro acetoacetate to give ethyl
2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate. The latter reacts
with PPA, HMTA and acetic acid to yield ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate.
These compounds further react with di-bromo alkane and 4-hydroxy coumarin to give the final thiazole derivatives. These are
characterized by elemental analysis, IR and 1H NMR spectra, and have
been screened for their antimicrobial activity and found to have significant
effect against the tested microorganisms. Some of the synthesized thiazole
derivatives are found to exhibit promising activity.
Synthesis and characterization of N-substituted 2-hydroxypyrrolidine/ piperidine derivatives using cerium chloride as catalyst
Title: Synthesis and characterization of N-substituted 2-hydroxypyrrolidine/ piperidine derivatives using cerium chloride as catalyst
Authors: Suresh, M; Khader, K K Abdul; Chandrasekaran, T; Padusha, M Syed Ali
Abstract: 2-Hydroxypyrrolidine/piperidine derivatives
have gained great interest in synthetic organic research because of their wide
range of biological activities. A series of pyrrolidine derivatives have been
synthesized using heterocyclic amines 5a-h
and 2,3-dihydro-furan 2a. Further, a
series of piperidine derivatives have been synthesized using 5a-h and 3,4-dihydro-2H-pyran 2b. Both 2a and 2b react with 5a-h via C-N
cross-coupling reaction and result in the products 6a-p. Acetonitrile and cerium chloride heptahydrate have been used
as solvent and catalyst respectively. The chemical structures of the newly
synthesized compounds have been elucidated by spectral analysis (viz., 1H and 13C
NMR and mass spectra) and analytical techniques. In the present study various
solvents and catalyst have been employed. Among them CeCl3.7H2O
and acetonitrile are found to be effective in these transformations, which lead
to complete conversion to the coupled products.
Quinoline alkaloids – Synthesis, molecular docking studies of atanine, 2-isopropylfuro [2,3-b] quinolines and 3,4-dihydro-2,2-dimethyl-2H-pyrano [2,3-b]quinolines
Title: Quinoline alkaloids – Synthesis, molecular docking studies of atanine, 2-isopropylfuro [2,3-b] quinolines and 3,4-dihydro-2,2-dimethyl-2H-pyrano [2,3-b]quinolines
Authors: Satheeshkumar, R; Kavitha, C.; Muthusankar, A; Shanmughavel, P; Prasad, K J Rajendra
Abstract: A simple and efficient route to synthesis of 3-prenyl-2-quinolinones,
2,2-dimethyl-2H-pyrano[2,3-b]quinolines has been developed.
3(1'-Carboxy-3-methylbut-1'-enyl)-2-quinolinones have been decarboxylated using
ethanolamine followed by Prevost’s reaction with HgO/I2/AcOH and
AgOAc/I2/AcOH to yield
and which on cyclization using a few drops of conc.H2SO4
in ethanol give 3,4-dihydro-2,2-dimethyl-2H-pyrano[2,3-b]quinolines. All the synthesized
compounds have been structurally well characterized by spectral studies. The
intermediates, 3-prenyl-2-quinolinones, were isolated and characterized.
Subsequently the molecular docking studies for the first time have been carried
out for all the synthesized compounds using the protein kinase Epidermal Growth
Factor Receptor (EGFR) inhibitors.
Synthesis and biological screening of novel pyrazole and isoxazole derivatives
Title: Synthesis and biological screening of novel pyrazole and isoxazole derivatives
Authors: Raundal, Hemant N; Jadhav, Rahul P; Patil, Amar A; Bobade, Vivek D
Abstract: Novel 1,5-disubstituted pyrazole and isoxazole
derivatives like, aryl 5-(3-fluoro-4-methoxyphenyl)-1H-pyrazole-3-carboxylic acid 8a-e,
[(aryl)-piperazin-1-yl]-[5-(3-fluoro-4-methoxyphenyl)-isoxazol-3-yl]-methanone 9a-e, aryl 5-(3-fluoro-
4-methoxyphenyl)-1H-pyrazole-3-carboxylic acid 10a-e have been synthesized and
characterized using IR, 1H NMR,
13C NMR and mass spectral analysis. All the synthesized compounds
have been screened for their antibacterial activity against S. aureus, E. coli, B. subtilis, P. aeruginosa, S. pyogenes, K. terrigena and K.
pneumoniae and antifungal activity against T. viride, A. flavus, A. brasillansis,
and C. albicans. Interestingly all
the synthesized compounds exhibit good antibacterial and antifungal activity.
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