Indian Journal of Chemistry: Sec B- Organic Chemistry including Medicinal Chemistry

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Published by: NISCAIR (CSIR)

Subjects: Chemistry

Indian Journal of Chemistry (Section B) is published by the National Institute of Science Communication and Information Resources (NISCAIR)-CSIR, New Delhi. This journal publishes articles in Organic and Medicinal Chemistry. It includes full length papers, notes and communications and short reviews. The monthly issues covers articles in organic reaction mechanism, theoretical organic chemistry, structure-activity relationships, medicinal chemistry, synthesis of chiral compounds, bio-organic chemistry, enzymes in organic synthesis, reagents in organic synthesis, heterocyclic compounds, phytochemistry (natural products), amino acids, peptides and proteins, spectroscopy in characterization of organic compounds, chemoenzymatic and enantioselective synthesis of organic compounds, synthesis of fullerenes, metal-catalyzed asymmetric reactions, bioactive plant products and combinatorial chemistry.

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Editor,
Dr. P Paravatharajan
email: prema@niscair.res.in


ISSN No. :    0376-4699
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Tris(pentafluorophenyl)borane catalyzed synthesis of cyanohydrins, cyanohydrin trimethylsilyl ethers and α-amino nitriles
Title: Tris(pentafluorophenyl)borane catalyzed synthesis of cyanohydrins, cyanohydrin trimethylsilyl ethers and α-amino nitriles

Authors: Yaragorla, Srinivasarao; Sudhakar, A; Kiranmai, N

Abstract: Tris(pentafluorophenyl)borane catalyzed synthesis of cyanohydrins and trimethylsilylcyanohydrin ethers from carbonyl compounds and α-amino nitriles from imines (Strecker synthesis) has been reported in the presence of trimethylsilylcyanide. The substrate diversity has been extensively studied; various aldehydes, ketones and imines are participating in the methodology. Simple and mild reaction conditions, low levels of catalyst loading and shorter reaction times and high yields are the highlights of this methodology, also the products formed here are very important building blocks in the several biologically active natural products.

Page(s): 1471-1475

Formation and thermal rearrangement of 4,4′-diarylmethyl-2,2′-diaryl- 4,4′- biimidazolin-5,5′-diones
Title: Formation and thermal rearrangement of 4,4′-diarylmethyl-2,2′-diaryl- 4,4′- biimidazolin-5,5′-diones

Authors: Begum, T Shalina; Sobha, T D; Shafi, P M

Abstract: Recrystallisation of 4-arylmethyl-2-aryl-2-imidazolin-5-ones from ethanol results in the formation of 4,4′-diarylmethyl-2,2′-diaryl-4,4′-biimidazolin-5,5′-diones. These products undergo a McLafferty type rearrangement to give one molecule of 4-arylmethyl-2-aryl-2-imidazolin-5-one and one molecule of 4-arylidene-2-aryl-2-imidazolin-5-one under mass spectrometric conditions. The same rearrangement is also found to occur on heating the compounds just above their melting points.

Page(s): 1468-1470

A convenient and green approach for the synthesis of 2H-indazolo[2,1-b]phthalazinetriones
Title: A convenient and green approach for the synthesis of 2H-indazolo[2,1-b]phthalazinetriones

Authors: Raghuvanshi, Dushyant Singh; Kumari, Kumkum; Allam, Bharat Kumar; Singh, Krishna Nand

Abstract: A high yielding and environmentally benign synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione derivatives has been achieved using silica-supported KHSO4 catalyst under solvent-free conditions. The methodology adopted is simple, versatile and requires no column chromatography.

Page(s): 1462-1467

Uncatalyzed synthesis of furo(2,3-d)pyrimidine-2,4(1H,3H)-diones in water and their antimicrobial activity
Title: Uncatalyzed synthesis of furo(2,3-d)pyrimidine-2,4(1H,3H)-diones in water and their antimicrobial activity

Authors: Sambavekar, P P; Aitawade, M M; Kolekar, G B; Deshmukh, M B; Anbhule, P V

Abstract: Furo(2,3-d)pyrimidine-2,4(1H,3H)-dione derivatives have been synthesized by environment-friendly three component condensation of cyclic 1,3-diketones, aromatic aldehyde, and aryl isocyanide under uncatalyzed conditions in water. The synthesized compounds have been tested for their antifungal and antibacterial activities. Most of the compounds exhibit good results against tested fungi and bacteria. The compound 5e has been found to be potentially active against Aspergillus oryzae while 5g show excellent zone of inhibition (39 mm) against Penicillium chrysogenum.

Page(s): 1454-1461

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