Indian Journal of Chemistry: Sec B- Organic Chemistry including Medicinal Chemistry

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Published by: NISCAIR (CSIR)

Subjects: Chemistry

Indian Journal of Chemistry (Section B) is published by the National Institute of Science Communication and Information Resources (NISCAIR)-CSIR, New Delhi. This journal publishes articles in Organic and Medicinal Chemistry. It includes full length papers, notes and communications and short reviews. The monthly issues covers articles in organic reaction mechanism, theoretical organic chemistry, structure-activity relationships, medicinal chemistry, synthesis of chiral compounds, bio-organic chemistry, enzymes in organic synthesis, reagents in organic synthesis, heterocyclic compounds, phytochemistry (natural products), amino acids, peptides and proteins, spectroscopy in characterization of organic compounds, chemoenzymatic and enantioselective synthesis of organic compounds, synthesis of fullerenes, metal-catalyzed asymmetric reactions, bioactive plant products and combinatorial chemistry.

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Editor,
Dr. P Paravatharajan
email: prema@niscair.res.in


ISSN No. :    0376-4699
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Synthesis of symmetrically / unsymmetrically substituted bisbenzimidazolesulphides of potential pharmacological interest
Title: Synthesis of symmetrically / unsymmetrically substituted bisbenzimidazolesulphides of potential pharmacological interest

Authors: Rao, S Srinivas; Mahesh, Putluru; Reddy, Ch Venkata Ramana; Dubey, P K

Abstract: 2-(1-Chloroethyl)-1H-benzimidazole 1a on condensation with 2-mercaptobenzimidazole 2a in methanol using triethylamine as a base under reflux for 3 hr yields 2-((1-(1H-benzimidazol-2-yl)ethyl)thio)-1H-benzimidazole 3a which on alkylation using two equivalents of alkylating agent under phase transfer catalyst (PTC) conditions gives N,N1-dialkylbisbenzimidazolesulphides 3b-e. Using this synthetic strategy, N,N1-unsymmetricallydialkylbis-benzimidazolesulphides 3f-q are prepared by condensing 2-(1-chloroethyl)-1H-benzimidazole 1a with N1-alkyl-2-mercaptoben-zimidazole 2b-e to obtain 3 followed by alkylation under PTC conditions.

Page(s): 698-702

Bioactive chemical constituents from the leaves of Lantana Camara L.
Title: Bioactive chemical constituents from the leaves of Lantana Camara L.

Authors: Patil, Gautam; Khare, Anand Bhushan; Huang, Keh-Feng; Lin, Fuh-Mei

Abstract: New compound 1 (Gautin), a new flavone glycoside with a unique aglycone moiety, with five flavone, acacetin-7-O-β--rutinoside 2, Tricin 3, Hispidulin 4, 3,5,7,8-tetra hydroxyl-6,3′-dimethoxy flavones 5 and Pectolinarigenin 10 and also six terpenoids (25S)-spirostan-5-ene-3β-21-diol-3-O-α--rhamnopyr-anosyl-(1,2)-[α--rhamnopyranosyl-(1,4)]-β--glucopyranoside 6, Ursolic acid 7, Lantanilic acid 8, Icterogenin 9, Betulonic acid 11 and Betulinic acid 12 have been isolated from the dried leaves of Lantana camara L. The structure of compound 1 (Gautin) assessed by spectroscopial analysis as 5,7-dihydroxy-6,3′,4′-trimethoxy isoflavone-5-O-α--rhamnopyrano-syl-7-O-β--arabino-pyranosyl-(1→4)-O-β--xylopyranoside. Three flavones 1, 2, 5 and one terpenoid 11 are isolated for the first time from this plant.

Page(s): 691-697

Novel thiadiazoles and triazoles from 4-chloro-3,5-dimethylphenol and their in vitro antibacterial screening
Title: Novel thiadiazoles and triazoles from 4-chloro-3,5-dimethylphenol and their in vitro antibacterial screening

Authors: Takate, S J; Karale, B K; Salve, S P; Kale, D V; Ghodechor, G S; Zaware, B H; Jadhav, S S

Abstract: 4-Chloro-3,5-dimethylphenol exhibits disinfectant properties. Its 1,3,4-thiadiazole and 1,2,4-triazole derivatives have been prepared. These novel compounds are characterized with the help of spectral techniques like IR, 1H NMR and mass spectrometry. These novel compounds have been screened in vitro for their antimicrobial activities.

Page(s): 687-690

Synthesis and fungicidal activity of some 8-aryl-3-(b-d-glucopyranosyl)-4-oxo-4H,5H-1,2,4-triazolo-[4,3-b]-1,4,2,6-dithiadiazine-1,1-dioxides
Title: Synthesis and fungicidal activity of some 8-aryl-3-(b-d-glucopyranosyl)-4-oxo-4H,5H-1,2,4-triazolo-[4,3-b]-1,4,2,6-dithiadiazine-1,1-dioxides

Authors: Srivastava, Alok Kumar; Pandey, Lokesh Kumar; Pandey, O P; Verma, Shipra

Abstract: 8-Aryl-3-(b-d-glucopyranosyl)-4-oxo-4H,5H-1,2,4-triazolo-[4,3-b]-1,4,2,6-dithiadiazine-1,1-dioxides 4 have been conveniently prepared from 8-aryl-4-oxo-4H,5H-1,2,4-triazolo-[4,3-b]-1,4,2,6-dithiadiazine-1,1-dioxides 2 by reaction of β-d-1,2,3,4,6-penta-O-acetylglucopyranose and iodine. Compounds 2 are synthesized by reported methods from 3-mercapto-5-aryl-1,2,4-triazole 1, chlorosulphonyl isocyanate and N-di-isopropyl-ethylamine in acetonitrile. All compounds have been tested in vitro for their antifungal activity against three fungal species Cephalosporium saccharii, Colletotrichum falcatum and Helminthosporium oryzae.

Page(s): 682-686

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