Indian Journal of Chemistry: Sec B- Organic Chemistry including Medicinal Chemistry

Jump to: navigation, search

Published by: NISCAIR (CSIR)

Subjects: Chemistry

Indian Journal of Chemistry (Section B) is published by the National Institute of Science Communication and Information Resources (NISCAIR)-CSIR, New Delhi. This journal publishes articles in Organic and Medicinal Chemistry. It includes full length papers, notes and communications and short reviews. The monthly issues covers articles in organic reaction mechanism, theoretical organic chemistry, structure-activity relationships, medicinal chemistry, synthesis of chiral compounds, bio-organic chemistry, enzymes in organic synthesis, reagents in organic synthesis, heterocyclic compounds, phytochemistry (natural products), amino acids, peptides and proteins, spectroscopy in characterization of organic compounds, chemoenzymatic and enantioselective synthesis of organic compounds, synthesis of fullerenes, metal-catalyzed asymmetric reactions, bioactive plant products and combinatorial chemistry.

Contact

Editor,
Dr. P Paravatharajan
email: prema@niscair.res.in


ISSN No. :    0376-4699
Recent articles
Subscribe to Recent articles by email

Enter your email address:

Synthesis of novel piperidino benzimidazole thiazolidinyl quinoline derivatives
Title: Synthesis of novel piperidino benzimidazole thiazolidinyl quinoline derivatives

Authors: Darsi, S S Praveen Kumar; Devi, B Rama; Naidu, A

Abstract: The synthesis of 5-((2-(4-(1H-benzoimidazol-2-yl)piperidino)-quinolin-3-yl)methylene)thiazolidine-2,4-dione 5a-c by the Knoevenagel condensation between 2-chloroquionoline-3-carboxaldehyde 1 with an active methylene group containing 2,4-thazolidinedione 2 in isopropyl alcohol using -proline as a catalyst followed by reaction with 2-(piperidino)-1H-benzoimidazole 3 in presence of triethylamine in THF is described. Alternatively, 5a-c were also synthesized from another reaction sequence 1 6 5.

Page(s): 142-145

Polyphosphoric acid catalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones by grinding under solvent-free conditions
Title: Polyphosphoric acid catalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones by grinding under solvent-free conditions

Authors: Zhao, Ying; Zhao, Yongguang; Zhang, Jianping; Liu, Hongmei; Liang, Liman

Abstract: 3,4-Dihydropyrimidin-2-(1H)-ones have been obtained, in high yield, by grinding ternary mixture of different substituted aromatic aldehydes, ethyl acetoacetate and urea, in the presence of polyphosphoric acid, under solventless conditions. The facile reaction condition, simple isolation and purification procedures of this method make it a good option for the synthesis of dihydropyrimidinones.

Page(s): 139-141

Green synthesis and antibacterial activity of 3-(3-aryl[1,8]naphthyridin-2-yl)-7-[1-[1,4-dioxo-1,2,3,4-tetrahydro-6-phthalazinyl]-2,2,2-trifluoro-1-(trifluoromethyl)ethyl]-2-(3-aryl [1,8]naphthyridin-2-yl)-1,2,3,4-tetrahydro-1,4-phthalazinediones
Title: Green synthesis and antibacterial activity of 3-(3-aryl[1,8]naphthyridin-2-yl)-7-[1-[1,4-dioxo-1,2,3,4-tetrahydro-6-phthalazinyl]-2,2,2-trifluoro-1-(trifluoromethyl)ethyl]-2-(3-aryl [1,8]naphthyridin-2-yl)-1,2,3,4-tetrahydro-1,4-phthalazinediones

Authors: Mogilaiah, K; Rao, A Nageswara; Rao, P Koteswara

Abstract: A simple and highly efficient procedure has been described for the synthesis of 3-(3-aryl[1,8]naphthyridin-2-yl)-7-[1-[1,4-dioxo-1, 2, 3, 4-tetrahydro-6-phthalazinyl]-2, 2, 2-trifluoro-1-(trifluoro-methyl)ethyl]-2-(3-aryl[1,8]naphthyridin-2-yl)-1,2,3,4-tetrahydro-1,4-phthalazinediones 3 by the condensation of 3-aryl-2-hydrazino-1,8-naphthyridines 1 with 4,4'-(hexafluoroiso-propylidene)diphthalic anhydride 2 in 2:1 molar ratio in the presence of catalytic amount of DMF under microwave irradiation/ in presence of catalytic amount of PTSA in the solid state at RT under grinding conditions. The products have been obtained in very good yields and in a state of high purity. The structures of the compounds 3 have been established on the basis of their spectral (IR and 1H NMR) and analytical data. The compounds 3 have been screened for their antibacterial activity.

Page(s): 135-138

Synthesis of novel sulfonamides as potential antibacterial, antifungal and antimalarial agents
Title: Synthesis of novel sulfonamides as potential antibacterial, antifungal and antimalarial agents

Authors: Mistry, B D; Desai, K R; Intwala, S M

Abstract: 4-Amino-2-chloro-5-(hydrazinocarbonyl)benzenesulfonamide 3 has been used as a precursor to synthesize some important biologically active heterocycles; which have been cyclized by treating with various aromatic acids in presence of POCl3 to give 4-amino-2-chloro-5-(5-substitutedphenyl-1, 3, 4-oxadiazol-2-yl) benzene sulfonamide 4a-j. Reaction of 4-amino-2-chloro-5-(hydrazinocarbonyl)benzenesulfonamide 3 with carbon disulphide in ethanol and potassium hydroxide yields the 1,3,4-oxadiazol derivatives 4. Condensation of this oxadiazole derivatives with different aromatic amines yields 4-amino-2-chloro-5-(5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl) benzene sulfonamide 5a-j and reaction of 4-amino-2-chloro-5-(hydrazinocarbonyl)benzenesul-fonamide 3 with chloroacetamide in 2-ethoxy ethanol yields 1,2,4-triazine derivatives 6 which upon condensation with different aromatic aldehydes in presence of sodium methoxide yields 4-amino-5-[(6Z)-6-substitutedbenzylidene-5-oxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl]-2-chlorobenzene sulfonamide 6a-j. The results indicate that some of the compounds show potential antibacterial, antifungal and antimalarial activity and comparable to those of commercial antibiotics and antimalarial compounds. The structures of novel synthesized compounds have been established on the basis of elemental analysis, IR, 1H NMR, 13C NMR and mass spectral data.

Page(s): 128-134

Back to Journals






About Us | Advertise on Indian Science | Contact Us
Copyright © 2007-2011 IndianScience.in