Published by: NISCAIR (CSIR)
Indian Journal of Chemistry (Section B) is published by the National Institute of Science Communication and Information Resources (NISCAIR)-CSIR, New Delhi. This journal publishes articles in Organic and Medicinal Chemistry. It includes full length papers, notes and communications and short reviews. The monthly issues covers articles in organic reaction mechanism, theoretical organic chemistry, structure-activity relationships, medicinal chemistry, synthesis of chiral compounds, bio-organic chemistry, enzymes in organic synthesis, reagents in organic synthesis, heterocyclic compounds, phytochemistry (natural products), amino acids, peptides and proteins, spectroscopy in characterization of organic compounds, chemoenzymatic and enantioselective synthesis of organic compounds, synthesis of fullerenes, metal-catalyzed asymmetric reactions, bioactive plant products and combinatorial chemistry.
Dr. P Paravatharajan
ISSN No. : 0376-4699
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Synthesis and anti-mycobacterial activity of 1H-1,2,3-triazolylisonicotinohydrazides
Title: Synthesis and anti-mycobacterial activity of 1H-1,2,3-triazolylisonicotinohydrazides
Authors: Dayakar, Ch; Suman, P; Rajkumar, K; Yogeeswari, P; Sriram, D; Raju, B China
Abstract: 1H-1,2,3-Triazolylisonicotinohydrazides (7a-d and 13a-f) have been prepared by the condensation of 1H-1,2,3-triazole-4-carbaldehydes (5a-d and 12a-f) with isonicotinylhydrazide (INH, 6) in good yields. All the synthesized compounds (7a-d and 13a-f) have been screened for their anti-mycobacterial activity. Compounds 7a, 7b and 13b display good anti-mycobacterial activity and these derivatives have been chosen for their cytotoxicity
Transformation of androstenedione into 17α-hydroxy-16β-methylpregn-4-ene-3,20-dione
Title: Transformation of androstenedione into 17α-hydroxy-16β-methylpregn-4-ene-3,20-dione
Authors: Huy, Luu D; Diep, N T; Thu, H P; Tuyen, N D; Chung, L T K; Vu, T K; Nam, N H; Savinova, Tatiana S
Abstract: An efficient synthesis of 17α-hydroxy-16β-methylpregn-4-ene-3,20-dione from androstenedione has been studied. Structure of the product and its intermediates has been examined by spectral methods such as IR, MS, 1D and 2D NMR.
Efficient three-component synthesis of diversely substituted tetrahydro-1H-cyclopenta[c]quinolines
Title: Efficient three-component synthesis of diversely substituted tetrahydro-1H-cyclopenta[c]quinolines
Authors: Niño, Patricia; Cabaa, Marta; Aguilar, Nuria; Terricabras, Emma; Albericio, Fernando; Fernàndez, Joan-Carles
Abstract: The synthesis of highly functionalized substituted tetrahydro-1H-cyclopenta[c]quinoline (I) and its reduced derivatives hexahydro-1H-cyclopenta[c]quinolines (II) via Povarov reaction in high diastereoselectivity and high to moderate yields is described herein. In addition, the relative stereochemistry of the α-substituent to the tetrahydroquinoline nitrogen, as well as the regioselectivity of reaction, is shown to depend upon subtle substituent effects on the aldehyde and aniline precursors. In most cases, a preference for the formation of endo diasteomeric adducts is observed but for reactions with ortho-substituted aldehydes, the formation of exo adducts is also observed. The exo-diastereoselectivity is found to be higher when the bulky size of this ortho group increases. Preparation of ortho and diortho-substituted aromatic aldehyde precursors of the Povarov reaction is also reported.
Synthesis and biological activity of novel derivatives of 2-(5-(3-fluro-4-methoxy phenyl)-1H-pyrazol-3-yl)-5-aryl-1,3,4-oxadiazole
Title: Synthesis and biological activity of novel derivatives of 2-(5-(3-fluro-4-methoxy phenyl)-1H-pyrazol-3-yl)-5-aryl-1,3,4-oxadiazole
Authors: Raundal, Hemant N; Jadhav, Rahul P; Patil, Amar A; Bobade, Vivek D
Abstract: A series of new 1,3,4-oxadiazole derivatives have been synthesized by condensation of 5-(3-fluro-4-methoxyphenyl)-1H-pyrazole-3-carbohydrazide with different substituted benzoic acids. All the synthesized compounds have been screened for antibacterial activity against S. aureus, E. coli, B. subtilis, P. aeruginosa, S. pyogenes, K. terrigena, K. Pneumoniae and antifungal activity against T. viride, A. flavus, A. brasillansis and C. albicans. Most of the synthesized compounds show good antimicrobial activity.
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