Indian Journal of Chemistry: Sec B- Organic Chemistry including Medicinal Chemistry

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Published by: NISCAIR (CSIR)

Subjects: Chemistry

Indian Journal of Chemistry (Section B) is published by the National Institute of Science Communication and Information Resources (NISCAIR)-CSIR, New Delhi. This journal publishes articles in Organic and Medicinal Chemistry. It includes full length papers, notes and communications and short reviews. The monthly issues covers articles in organic reaction mechanism, theoretical organic chemistry, structure-activity relationships, medicinal chemistry, synthesis of chiral compounds, bio-organic chemistry, enzymes in organic synthesis, reagents in organic synthesis, heterocyclic compounds, phytochemistry (natural products), amino acids, peptides and proteins, spectroscopy in characterization of organic compounds, chemoenzymatic and enantioselective synthesis of organic compounds, synthesis of fullerenes, metal-catalyzed asymmetric reactions, bioactive plant products and combinatorial chemistry.

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Editor,
Dr. P Paravatharajan
email: prema@niscair.res.in


ISSN No. :    0376-4699
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Synthesis and anti-bacterial evaluation of 4-aryloxymethyl carbostyrils derived from substructures and degradation products of Vancomycin
Title: Synthesis and anti-bacterial evaluation of 4-aryloxymethyl carbostyrils derived from substructures and degradation products of Vancomycin

Authors: Revankar, Hrishikesh M; Arali, Shweta; Yakkerimath, Shilpa; Revankar, Pooja P; Naik, Vijaykumar; Anand, Ashish; Kulkarni, Manohar V

Abstract: Vancomycin has been used as an antibiotic selectively against Gram-positive bacteria; however in the past decade they have grown resistant against it. The present work describes synthesis of a series of 4-aryloxymethyl carbostyrils derived from the reaction of 4-bromomethyl carbostryils with degradation products of Vancomycin (ethyl gallate and ethyl ester of N-benzoyl tyrosine ethyl ester). Further, gallate ethers 4a-d and tyrosine ethers 5a-d have been found to be selectively active against Gram-positive bacteria.

Page(s): 637-642

Catalyst and solvent free one-pot microwave synthesis of fused pyrimidine diones and triones
Title: Catalyst and solvent free one-pot microwave synthesis of fused pyrimidine diones and triones

Authors: Sontakke, Madhuri M; Dhonde, Madhukar G; Bhaskar, Chandrakant S; Berad, Baliram N

Abstract: One pot three components synthesis of fused pyrimidine diones and triones have been achieved by reaction of barbituric acids, aldehydes and monosubstitued carbamides or thiocarbamides under microwave irradiation. The mild reaction conditions, easy product work-up, and good to high yields are some of the highlight of the present protocol. The method is applicable to the synthesis of variously substituted fused pyrimidine diones and thiones. This method offers substantial improvements in the reaction rates and yields, and also avoids the use of hazardous solvent and catalyst apart from applicability to the wide variety of substrates.

Page(s): 629-636

Aerobic oxidation of aromatics catalyzed by CoSPc and NHPI
Title: Aerobic oxidation of aromatics catalyzed by CoSPc and NHPI

Authors: Zhou, Yulu; Lin, Shasha; Bian, Yinghui; Xia, Daohong; Xiang, Yuzhi

Abstract: An efficient method to convert aromatics into the corresponding oxides, catalyzed by a combined catalytic system consisting of CoSPc and NHPI, has been developed. The products have been diversified with the number of hydrogen atoms on the benzyl positions. When only one hydrogen atom is present on the benzyl position, a C-C bond dissociation occurs, if there are two or three hydrogen atoms present on the benzyl positions, carbonyl or carboxyl products are generated. Whether the oxidation takes place or not mainly depends on the BDEs of benzyl C-H bonds, steric hindrances only influence the oxidation speeds, and an oxidation process is proposed at the end of discussion.

Page(s): 624-628

Ultrasound accelerated synthesis of novel benzimidazole derived chalcones as glucosidases inhibitor and antimicrobial agents
Title: Ultrasound accelerated synthesis of novel benzimidazole derived chalcones as glucosidases inhibitor and antimicrobial agents

Authors: Meshram, Gangadhar A; Vala, Vipul A; Wagh, Pramod A; Deshpande, Shruti S

Abstract: A novel series of 3-substituted-1-[1-(toluene-4-sulfonyl)-1H-benzoimidazol-2-yl]-propen-1-one 3a-m have been synthesized by tosylation of benzimidazole chalcones 2a-m using ultrasound in lesser time with higher yields. All the synthesized compounds have been characterized by IR, 1H and 13C NMR, mass and elemental analysis in full accordance with their depicted structure. Biological evaluation of the compounds 3a-m reveals that compound 3f shows moderate inhibition of glucoamylase and compound 3i exhibits compelling inhibition of α-amylase. Compound 3k and 3d display excellent antibacterial activity against all tested strains and admirable antifungal activity against Candida albicans respectively in comparison to the standards. The results of biological study show that introduction of tosyl group in benzimidazole chalcones enhances the inhibition of glycosidases and microorganism in comparison to parent compounds.

Page(s): 613-623

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