Indian Journal of Chemistry: Sec B- Organic Chemistry including Medicinal Chemistry

Published by: NISCAIR (CSIR)

Subjects: Chemistry

Indian Journal of Chemistry (Section B) is published by the National Institute of Science Communication and Information Resources (NISCAIR)-CSIR, New Delhi. This journal publishes articles in Organic and Medicinal Chemistry. It includes full length papers, notes and communications and short reviews. The monthly issues covers articles in organic reaction mechanism, theoretical organic chemistry, structure-activity relationships, medicinal chemistry, synthesis of chiral compounds, bio-organic chemistry, enzymes in organic synthesis, reagents in organic synthesis, heterocyclic compounds, phytochemistry (natural products), amino acids, peptides and proteins, spectroscopy in characterization of organic compounds, chemoenzymatic and enantioselective synthesis of organic compounds, synthesis of fullerenes, metal-catalyzed asymmetric reactions, bioactive plant products and combinatorial chemistry.

Contact

Editor,
Dr. P Paravatharajan
email: prema@niscair.res.in

ISSN No. :    0376-4699

Synthesis of a novel water soluble phthalimide derivative of acetaminophen as potential analgesic and antipyretic agent
Title: Synthesis of a novel water soluble phthalimide derivative of acetaminophen as potential analgesic and antipyretic agent

Authors: Reddy, Y Dathu; Kumari, Y Bharathi; Dubey, P K

Abstract: A short process for the preparation of water soluble, potential analgesic compound, N-[(4-hydroxy-phenylcarbamoyl)-methyl]-phthalamic acid 4 has been developed. Two synthetic routes (A and B) have been established for the preparation of 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-N-(4-hydroxyphenyl)acetamide 3. In route A, 4-aminophenol 5 is reacted with chloroacetyl chloride 6 in solution of potassium acetate and acetic acid at 0-5°C to yield N-(4-hydroxyphenyl)-2-chloroacetamide 7. The latter is reacted with potassium phthalimide 8 and KI in DMF at 130°C to give 3. Alternatively, in route B, reaction of phthalic anhydride 8 with glycine 9 at 150°C yields the acid intermediate (1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetic acid 11, which on reaction with 4-aminophenol 6 in DMF and in the presence of dicyclo­hexylcarbodimide gives 3. The latter is hydrolysed in ethanolic KOH to afford 4.

Page(s): 691-693

Studies on reactions of anhydrides with Schiff bases
Title: Studies on reactions of anhydrides with Schiff bases

Authors: Kumar, Padam Praveen; Mohiuddin, S M G; Devi, B Rama; Dubey, P K

Abstract: Reaction of phthalic anhydride 1 with benzylidineanilines 2, in equimolar ratio in hot acetic acid, yields N-arylphthalimides 3. Compound 1 reacts with the arylimine part of the Schiff base eliminating benzaldehyde part 4 as the bye-product. This reaction of 1 with 2 is also found to occur with other anhydrides like succinic anhydride 5, maleic anhydride 7 and acetic anhydride 9 resulting in the formation of the corresponding N-arylimides, namely, succinicimide 6, maleicimide 8 and aceticimide 10 respectively. In all the above reactions, the by-product, i.e. benzaldehyde or p-chlorobenzaldehyde can be isolated and characterized as its 2,4-dinitrophenylhydrazone derivative. Probable mechanism for the formation of imides from the corresponding anhydrides and Schiff bases has been suggested.

Page(s): 686-690

Synthesis of some new isoxazolyldihydro[1,2,4]triazolo[1,5-b] isoxazoles and dihydroimidazo[4,5-b]indolylisoxazoles as possible biodynamic agents
Title: Synthesis of some new isoxazolyldihydro[1,2,4]triazolo[1,5-b] isoxazoles and dihydroimidazo[4,5-b]indolylisoxazoles as possible biodynamic agents

Authors: Rajanarendar, E; Venkateshwarlu, P; Ramakrishna, S

Abstract: Synthesis of new isoxazolyl[1,2,4]triazolo[1,5-b]isoxazoles and imidazo[4,5-b]indolyl isoxazoles have been achieved by interaction of isoxazole Schiff base with isoxazole amines and isatin respectively.

Page(s): 677-685

Antimicrobial evaluation of some novel isoxazoles, cyanopyridines and pyrimidinthiones
Title: Antimicrobial evaluation of some novel isoxazoles, cyanopyridines and pyrimidinthiones

Authors: Solankee, Anjani; Patel, Kirti; Patel, Rajnikant

Abstract: The title compounds 7a-f, 8a-f and 9a-f have been prepared from chalcones 6a-f having s-triazine nucleus. These chalcones on cyclisation with hydroxyl amine hydrochloride in the presence of alkali and malononitrile in the presence of ammonium acetate give isoxazoles 7a-f and cyanopyridines 8a-f respectively. Chalcones 6a-f on condensation with thiourea in the presence of alkali give pyrimidinthiones 9a-f. Structures of newly synthesised compound have been established on the basis of their elemental analysis, IR and ¹H NMR spectral data. All the synthesised compounds have been screened for their antimicrobial activity.

Page(s): 671-676

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