Indian Journal of Chemistry: Sec B- Organic Chemistry including Medicinal Chemistry

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Published by: NISCAIR (CSIR)

Subjects: Chemistry

Indian Journal of Chemistry (Section B) is published by the National Institute of Science Communication and Information Resources (NISCAIR)-CSIR, New Delhi. This journal publishes articles in Organic and Medicinal Chemistry. It includes full length papers, notes and communications and short reviews. The monthly issues covers articles in organic reaction mechanism, theoretical organic chemistry, structure-activity relationships, medicinal chemistry, synthesis of chiral compounds, bio-organic chemistry, enzymes in organic synthesis, reagents in organic synthesis, heterocyclic compounds, phytochemistry (natural products), amino acids, peptides and proteins, spectroscopy in characterization of organic compounds, chemoenzymatic and enantioselective synthesis of organic compounds, synthesis of fullerenes, metal-catalyzed asymmetric reactions, bioactive plant products and combinatorial chemistry.

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Editor,
Dr. P Paravatharajan
email: prema@niscair.res.in


ISSN No. :    0376-4699
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Synthesis of a new class of bis heterocycles
Title: Synthesis of a new class of bis heterocycles

Authors: Padmavathi, Venkatapuram; Sreelatha, Tumma; Reddy, Putta Ramachandra; Divya, Kuppireddygari

Abstract: A variety of bis heterocycles-oxazolyl / thiazolyl / imidazolyl pyrroles and pyrazoles have been prepared adopting 1,3-dipolar cycloaddition of tosylmethyl isocyanide and diazomethane to oxazolyl / thiazolyl / imidazolyl acrylamides.

Page(s): 1295-1300

Catalyst-free access to pseudo multi-component synthesis of benzopyranopyrimidines
Title: Catalyst-free access to pseudo multi-component synthesis of benzopyranopyrimidines

Authors: Shaikh, T S; Patil, J D; Gaikwad, D S; Hegade, P G; Patil, P B; Undale, K A; Mane, M M; Pore, D M

Abstract: A catalyst-free multi-component reaction of salicylaldehyde, malononitrile and secondary amine leads to the formation of benzopyranopyrimidines with intense fluorescence emission behavior is described. The method is simple, eco-friendly, economic, operable under mild conditions, having short reaction time, high yields and easy work-up procedure which suggests broad applicability of the protocol.

Page(s): 1288-1294

Lupane-triterpenoids from stem bark of Dillenia indica
Title: Lupane-triterpenoids from stem bark of Dillenia indica

Authors: Ghosh, Partha Sarathi; Sarma, Indrajit Sil; Sato, Noriko; Harigaya, Yoshihiro; Dinda, Biswanath

Abstract: A new lupane-triterpene acid ester, dillenic acid 1 along with four known compounds, betulinic acid 2, 3-epi-betulinic acid 3, 3-epi-dihydrobetulinic acid 4 and 3α-hydroxy-lup-20(29)-en-23,28-dioic acid 5 have been isolated from the stem bark of Dillenia indica Linn (Dilleniaceae). Based on spectroscopic and chemical data, the structure of the new compound 1 was determined as 3α-(2-hydroxyhexanoyloxy)-lup-20(29)-en-28-oic acid. Known compounds 3-5 has been reported for the first time from this plant.

Page(s): 1284-1287

Synthesis of novel isoxazolo[2'',3'':1',2']pyrimido[4',5':4,5]pyrimido- [6,1-b]quinazoline-8-ones and their in vitro anticancer and antimicrobial activities
Title: Synthesis of novel isoxazolo[2'',3'':1',2']pyrimido[4',5':4,5]pyrimido- [6,1-b]quinazoline-8-ones and their in vitro anticancer and antimicrobial activities

Authors: Rajanarendar, E; Kishore, B; Ramakrishna, S; Nagaraju, D; Venkateshwarlu, P

Abstract: Synthesis of novel isoxazolo[2'',3'':1',2']pyrimido[4',5':4,5]pyrimido[6,1-b]quinazoline-8-ones 6a-j, has been achieved by reaction of 5-amino-2-methyl-7-phenyl-7H-isoxazolo[2,3-a] pyrimidin-6-yl cyanides 4, with dimethyl formamide dimethylacetal followed by treatment with anthranilic acids in situ in one-pot. The key intermediate, viz., 5-amino-2-methyl-7-phenyl-7H-isoxazolo[2,3-a]pyrimidin-6-yl cyanide 4 is obtained by reaction of 3-amino-5-methyl isoxazole with aromatic aldehydes and malononitrile by a three-component one-pot process. The newly synthesized compounds 6a-j have been evaluated for their in vitro anticancer and antimicrobial activity. Compounds 6e and 6f exhibit potent anticancer and antimicrobial activity comparable to that of standard drugs.

Page(s): 1275-1283

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