Indian Journal of Chemistry: Sec B- Organic Chemistry including Medicinal Chemistry

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Published by: NISCAIR (CSIR)

Subjects: Chemistry

Indian Journal of Chemistry (Section B) is published by the National Institute of Science Communication and Information Resources (NISCAIR)-CSIR, New Delhi. This journal publishes articles in Organic and Medicinal Chemistry. It includes full length papers, notes and communications and short reviews. The monthly issues covers articles in organic reaction mechanism, theoretical organic chemistry, structure-activity relationships, medicinal chemistry, synthesis of chiral compounds, bio-organic chemistry, enzymes in organic synthesis, reagents in organic synthesis, heterocyclic compounds, phytochemistry (natural products), amino acids, peptides and proteins, spectroscopy in characterization of organic compounds, chemoenzymatic and enantioselective synthesis of organic compounds, synthesis of fullerenes, metal-catalyzed asymmetric reactions, bioactive plant products and combinatorial chemistry.

Contact

Editor,
Dr. P Paravatharajan
email: prema@niscair.res.in


ISSN No. :    0376-4699
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Synthesis of chenopanone
Title: Synthesis of chenopanone

Authors: Deore, Prashant S; Argade, Narshinha P

Abstract: Starting from glyoxalic acid, a facile three step approach to chenopanone has been described utilizing the Barbier reaction as a key step.

Page(s): 1140-1142

Development and validation of ultraperformance liquid chromatography (UP-LC) method for estimation of a new anti-diabetic drug linagliptin in bulk and its tablet formulation
Title: Development and validation of ultraperformance liquid chromatography (UP-LC) method for estimation of a new anti-diabetic drug linagliptin in bulk and its tablet formulation

Authors: Dubey, Nidhi; Singh, G N; Tyagi, Anchal; Bhardwaj, Rakesh; Raghav, C S

Abstract: A simple, precise and accurate isocratic reversed-phase ultra performance liquid chromatography (UP-LC) method has been developed and validated for determination of linagliptin in bulk and its pharmaceutical formulation. Isocratic separation has been achieved on an Agilent SB-C18 RRHD (50 mm × 2.1 mm, 1.8 μm) column using mobile phase of 0.01 M potassium phosphate H 4.0 and acetonitrile (30:70) at a flow rate of 0.3 mL per min. The injection volume is 2.0 μL and the detection has been carried out at 292 nm by using photo-diode array detector. The method has been validated as per ICH guidelines for specificity, linearity, precision, accuracy, robustness and ruggedness. The method is linear in the drug concentration range of 0.5-100 μg/mL with a correlation coefficient of 0.9998. The accuracy (recovery) is between 97.81% and 100.51%. The proposed method offers significant advantages over the reported methods, as the former is more sensitive and selective, has a short analysis time i.e. 5.0 min. (Rt for linagliptin is 1.5 min), good accuracy and precision, having the LOD and LOQ value 0.25 μg/mL and 0.5 μg/mL.

Page(s): 1136-1139

Synthesis and evaluation of some N-Mannich bases of isoindole-1,3(2H)-dione derivatives as potential antimicrobial, anthelmintic and insecticidal agents
Title: Synthesis and evaluation of some N-Mannich bases of isoindole-1,3(2H)-dione derivatives as potential antimicrobial, anthelmintic and insecticidal agents

Authors: Bamnela, Rita; Shrivastava, S P

Abstract: A series of some novel N-Mannich bases of benzimidazolyl substituted 1H-isoindole-1,3(2H) dione have been synthesized by cyclo-condensation of phthalic anhydride with different amino acids and thereafter, condensed with o-phenylenediamine following the Mannich protocol with different amines and formaldehyde to yield the titled compounds 5a-k. The structures of the newly synthesized compounds have been confirmed by FTIR, 1H NMR, mass spectral studies and elemental analyses. All the synthesized compounds have been evaluated for their in vitro antimicrobial, anthelmintic and insecticidal activities against selected microbes, helminthes and insects, compared to standard drugs streptomycin, nystatin, piperazine hydrochloride and cypermethrin respectively. Synthesized compounds 5d, 5j and 5k have shown promising activity against all selected microbes, helminthes and insects, while 5b is strongly toxic against S. aureus, 5g and 5k against B. subtilis, 5i against K. pneumoniae, 5a against T. viride and C. albicans, and 5h against A. niger. Compounds 5f, 5h, 5j, and 5k exhibited good antifungal activity, while 5b, 5g, 5e and 5i are sufficiently toxic for selected bacterial strains. Compounds 5a, 5b, 5c, 5e and 5f are strongly toxic against selected helminthes, while 5a, 5b, 5f, 5g, 5h and 5i have shown promising insecticidal activity.

Page(s): 1128-1135

Ferric nitrate nonahydrate as a mild and efficient catalyst for the synthesis of β-enaminones
Title: Ferric nitrate nonahydrate as a mild and efficient catalyst for the synthesis of β-enaminones

Authors: Khajuria, Rajni; Ambica; Saini, Yeshwinder; Kapoor, Kamal K

Abstract: Ferric nitrate nonahydrate (Fe(NO3)3.9H2O) has been found to be an extremely mild and efficient catalyst for the preparation of β-enaminones from β-dicarbonyl compounds and amines (aliphatic amines, aromatic amines and α-amino acid esters).

Page(s): 1122-1127

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