Indian Journal of Chemistry: Sec B- Organic Chemistry including Medicinal Chemistry

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Published by: NISCAIR (CSIR)

Subjects: Chemistry

Indian Journal of Chemistry (Section B) is published by the National Institute of Science Communication and Information Resources (NISCAIR)-CSIR, New Delhi. This journal publishes articles in Organic and Medicinal Chemistry. It includes full length papers, notes and communications and short reviews. The monthly issues covers articles in organic reaction mechanism, theoretical organic chemistry, structure-activity relationships, medicinal chemistry, synthesis of chiral compounds, bio-organic chemistry, enzymes in organic synthesis, reagents in organic synthesis, heterocyclic compounds, phytochemistry (natural products), amino acids, peptides and proteins, spectroscopy in characterization of organic compounds, chemoenzymatic and enantioselective synthesis of organic compounds, synthesis of fullerenes, metal-catalyzed asymmetric reactions, bioactive plant products and combinatorial chemistry.

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Editor,
Dr. P Paravatharajan
email: prema@niscair.res.in


ISSN No. :    0376-4699
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Synthesis of some active and new E-2-(4-anisyl)-3-arylidene chromanone
Title: Synthesis of some active and new E-2-(4-anisyl)-3-arylidene chromanone

Authors: Bairwa, Ved Prakash; Jain, Prerna; Sharma, B S

Abstract: A set of nine 3-arylidene chromanone have been synthesized by simple acid catalyzed condensation of appropriate 2-(4-anisyl) chromanone and substituted benzaldehyde using dry hydrogen chloride gas. Piperidine has been used as catalyst for the synthesis of 2-(4-anisyl)-3-arylidene chromanone. The structural assignments of the title compounds have been carried out using elemental analysis, IR and 1H NMR spectral studies.

Page(s): 430-433

Synthesis and in vitro biological screening of some benzimidazolyl anchored azoles
Title: Synthesis and in vitro biological screening of some benzimidazolyl anchored azoles

Authors: Karale, B K; Nirmal, P R; Akolkar, H N

Abstract: A series of novel thiadiazoles and triazoles anchored with benzimidazole have been synthesized and evaluated for their biological activities.

Page(s): 399-405

Rational design and synthesis of benzothiazolo-isatins for antimicrobial and cytotoxic activities
Title: Rational design and synthesis of benzothiazolo-isatins for antimicrobial and cytotoxic activities

Authors: Bari, Sanjay; Manda, Sarangapani; Ugale, Vinod; Jupally, Venkateshwar Rao; Akena, Venkatesham

Abstract: In search of novel antimicrobial agents, a series new isatin derivatives 3a-p and 5a-p have been synthesized by condensation of isatins with 2-mercaptobenzothiazole acetic acid hydrazide and 2-hydrazinobenzothiazole respectively. Compounds synthesized have been evaluated for antibacterial and antifungal activity against various strains of bacteria and fungi as well as screened for their cytotoxic activity against HeLa and HBL-100 cell lines by MTT method. Some of the compounds 3k, 5j and 5o show significant antibacterial and antifungal activities when compared with standard drugs. Amongst them, compound 3k has been found to be relatively more effective and it is also observed that its action is against all the four strains of bacteria tested. Compound 5j shows noticeable degree of inhibition, specifically against gram-positive strains B. subtilis and S. aureus with average zone of inhibition 23 mm and 34 mm respectively. Compound 3a shows good antifungal action against both C. albicans and A. niger with average zone of inhibition 10 mm each. The compound 3g is found to be most significant with IC50 values of 154.59 µM and 261.99 µM against HeLa and HBL-100 cell lines, respectively.

Page(s): 418-429

Characterization and antitubercular activity of synthesized pyrimidine derivatives via chalcones
Title: Characterization and antitubercular activity of synthesized pyrimidine derivatives via chalcones

Authors: Faldu, Viral J; Gothalia, Vrajlal K; Shah, Viresh H

Abstract: In the present investigation m-phenoxybenzaldehyde on condensation with various aromatic acetophenone in methanol and 40% aqueous solution of KOH has yielded the corresponding chalcones 4a-h. These chalcones have been further reacted with guanidine hydrochloride, thiourea and urea in the presence of alcoholic KOH, which has led to the formation of pyrimidine derivatives 5a-h to 7a-h. The newly synthesized heterocycles have been characterized on the basis of their chemical properties and spectroscopic data. All novel synthesized derivatives have been screened for their antimycobacterial activities against Mycobacterium tuberculosis H37Rv.

Page(s): 391-398

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