International Journal of Advances in Pharmaceutical Analysis
Published by: Scholar Science Journals
Subjects: Pharmaceutical Science
Our mission is to advance the science and practice of pharmaceutical analysis by working to develop and maintain competence, ethics and integrity and the highest professional standards in the specialty for the benefit of the public. The Faculty seeks, through its activities, to bring about an improvement in the health of the public. The areas of interest of International Journal of Pharmaceutical Analysis are: * Analytical Research and Development * Analytical Services for Medical Devices * Chemical Imaging * Instrumentation * Comparator Studies * Drug analysis * Elemental Analysis and Trace Metals * GLP & GMP Method Development, Validation and Remediation * NMR Analysis for Pharmaceuticals * NMR Analysis for Counterfeit Drugs * Pharmaceutical Auditing * Physical Characterization Techniques for Pharmaceuticals * Stability and Pharmaceutical Testing
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ISSN No. : 2277-9353
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Development and Validation of Stability Indicating RP-HPLC Method for Estimation of Rilpivirine Hydrochloride in Tablet Dosage Form
In the present study herbal products marketed in Yavatmal India were determined for the presence of microbial. Microbial contents in herbal products were examined as suggested in as per W.H.O. The total of ten herbal products of various brands were selected randomly and tested for microbial contamination. Of which 3 samples did not conform to the W.H.O guidelines. The formulations are used daily by the patients suffering from Liver diseases. The specific medias were used to determining the presence of Escherichia coli (4 samples), Staphylococcus aureus (3 samples), and P. aeruginosa (4 samples). The data indicated suggest that there is requirement of in process improvement to provide better quality for consumer health in order to be competitive in international markets.
Stress degradation of Lisinopril as per ICH Guidelines & Characterisation
Lisinopril an antihypertensive drug was subjected to stress degradation, since the drug is photosensitive undergo hydrolysis and oxidized in presence of oxygen. Hence the objective of the study was to stress degrade Lisinopril & to find out the pathway for stress degradation of Lisinopril. Stress testing methods are screening methods to be used to understand the degradation chemistry of a drug. Lisinopril was subjected to stress degradation under different conditions recommended by International Conference on Harmonization (ICH). The chromatographic separation of Lisinopril & its degradation products was done on C18 column & mobile phase was mixture of Methanol & Water in ratio 80:20, pH 3.5 adjusted with orthophosphoric acid at a flow rate of 1ml/min using UV detector with λmax 220nm. The quantification & characterizations of degraded products were carried out by UV, IR spectroscopy & HPLC. The mechanism of degradation was confirmed by GC-MS fragmentation pattern.
Quantitative analysis of Amoxicillin and Dicloxacillin in Combined Dosage Form by First Derivative and Simultaneous Equation Method in Application to the determination of Content Uniformity
Two simple, accurate and precise spectrophotometric methods have been developed for the simultaneous estimation of Amoxicillin and Dicloxacillin. Method A was quantitative determination of Amoxicillin and Dicloxacillin by First Order Derivative zero crossing method. The first order derivative absorption at 231.02 nm (zero cross point of Dicloxacillin) was used for Amoxicillin and 246.26nm (zero cross point of Amoxicillin) for Dicloxacillin. Both the drugs obeyed the limit 15-35µg/ml (correlation coefficient r2<1). No interference was found between the both determined constituents and those of matrix. Method B was developed for estimation of content uniformity of Amoxicillin and Dicloxaciliin in its combined tablet dosage form. The method involves solving the simultaneous equation using 245nm and 227nm as two wavelengths for Amoxicillin and Dicloxacillin respectively. From the results, it was concluded that all brands are within the limits of content uniformity (85-115%). 0.1 N sodium hydroxide was used as a solvent for both methods. Developed method was employed to determine the Amoxicillin and Dicloxacillin content in ten individual capsule units of four marketed formulations. Both the methods were validated statistically and recovery studies were carried out to confirm the accuracy of the methods.
Quantification of cinnarizine and dimenhydrinate in tablet dosage form by simultaneous equation spectrophotometric method
Validated RP-HPLC method for determination of related substances of montelukast from montelukast sodium chewable tablets
The development of a RP-HPLC method for Montelukast in the presence of its impurity and degradation product generated from force degradation studies drug was exposed through various degradation stress conditions and found to be stable column used BDS Hypersil C18 (250 mm x 4.6mm) 5um. Mobile phase was used in mixture of Buffer and Acetonitrile (30:70, v/v). The HPLC method was developed and validated with respect to linearity, precession, accuracy, ruggedness and specificity.
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