Journal of Integrated Science and Technology

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Published by: Integrated Science Publications

Subjects: InterDisciplinary Science and Technology

The Journal of Integrated Science and Technology (JIST) is official journal of IndianScience.in published by Indian Science Publications division. The journal publishes peer-reviewed articles from research in Science & Technology. The articles published cover different areas of Sciences and Technology viz., Chemical Sciences, Physics, Biotechnology, Microbiology, Biochemistry & Bioinformatics, Botany & Environmental Sciences, Pharmacy & Pharmacology, Agriculture, Animal Sciences, Entomology & Toxicological Sciences, Fisheries, Food Science & Nutrition, Physical Education & Sports Sciences, Health Sciences, Marine Biology, Material Sciences, BioEngineering, BioEthics, BioMedical Engineering and many more branches in the field of Science and Technology. Journal of Contemporary Science and Technology covers Research Articles, Reviews, Science & Technology Education, Popular Articles and Conference proceedings. Articles with multidisciplinary/interdisciplinary nature are promoted to foster a better understanding of the multidimensional nature of research. Industrial designs and and educational articles are published in special section.

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Elemental analysis of one rupee Indian coins by using EDXRF technique

Elemental analysis of some Indian coins of one rupee has been carried out by Energy Dispersive X-ray Fluorescence (EDXRF) technique which is non destructive, rapid and multi elemental in nature. The present investigation has been made for coins of different years for their elemental compositions with EDX-720 spectrometer equipped with Si(Li) detector having energy resolution 165 eV at 5.9 keV Mn K X-rays. This study observed the presence of Cu, Ni, Fe and Cr as the major elements.



Hydroxyethylamine Based Small Molecules as Inhibitors of BACE-1

β-Secretase or BACE-1 is a popular target for the treatment of Alzheimer disease (AD) and responsible for the formation of amyloid-β peptide. In recent years BACE-1 has emerged as one of the best characterized targets for Alzheimer therapy. The inhibition of BACE-1 activity is a crucial step for the treatment of AD. This mini-review summarizes some popular BACE-1 inhibitors possessing hydroxyethylamine and peptide scaffolds.



A Concise Review on Cyclin Dependent Kinase 5 (CDK5) Inhibitors
Cyclin dependent kinases 5 (CDK5) carry out many critical roles in the process of cell cycling and play an important role in many physiological functions, including development of central nervous system and their inhibitors have been extensively researched as therapeutic agents in the diagnosis of cancer. CDK5 belongs to Serine/Threonine Cyclin-dependent kinase (cdk) family. CDK5/ p25 complex has emerged as one of the potent principle therapeutic target for various diseases like acute and chronic neurodegenerative disease, including Alzheimer’s disease. Excessive upregulation of CDK5 leads to several types of neurodegenerative disorders like Alzheimer’s disease (AD), Amyotrophic lateral sclerosis (ALS), Niemann pick type C disease and Ischemia. To inhibit the excessive activity of cdk5, several cdk5 inhibitors have been synthesized and discovered naturally by various research groups globally here in this review we are accounting some of them together to show their efficacy.

Structural analysis and dielectric characterization of Aurivillius type CaSrBi2Nb2O9 ceramics

This work describes synthesis of powdered materials belonging to the Aurivillius oxide family (Bi2O2)2+(An-1BnO3n+1)2- for n = 2 and provides an approach for understanding the structural evolution with composition. The effect of strontium doping on the lattice response and dielectric properties of Ca1-xSrxBi2Nb2O9 (x = 0.0, 0.5, 1.0) ferroelectric ceramics is studied. The XRD studies revealed single phase formation of orthorhombic structure. The average crystallite size was obtained in the range 22-41 nm. The dielectric properties, viz. dielectric constant, loss tangent and ac electrical conductivity of the samples were studied by using impedance spectroscopy. A strong low frequency dielectric dispersion was found to exist in these samples. Its occurrence was ascribed to the presence of ionized space charge carriers such as oxygen vacancies. The relationship among doping, crystal structure, and dielectric properties were also discussed. Measurements of the dielectric permittivity as a function of temperature reveal signs of single phase transition. The thermal activation energy for the grain electric conductivity was lower in the high temperature region (Ea(ht) = 0.08 eV) and higher in the low temperature region (Ea(lt) = 0.21 eV).



Steady State availability analysis of a Physical System: Sole lasting system of Shoe Industry
This paper deals with the performance analysis of sole lasting system of a shoe industry using Markovian approach. The plant is divided into many sections like shoe upper manufacturing system, sole lasting system and sole pasting system. In the present work sole lasting system has been taken for performance analysis. The system consists of six subsystems namely, Toe Humidifier Machine, Toe Lasting Machine, Heel Humidifier Machine, Heel Lasting Machine, Heating Chamber Machine and Rubbing & Buffing machine. Failure and repair rates of these subsystems are assumed to be constant and exponentially distributed. A mathematical model pertaining to the real environment of shoe industry has been developed using Markov birth-death process.  The differential equations have been derived on the basis of probabilistic approach using transition diagram. These equations are solved using normalizing conditions and recursive method to derive out the steady state availability expression of the system i.e. system’s performance criterion. The results give system availability for different combinations of failures and repair rates for various subsystems.

Study of Antioxidant Potential of Solanum tuberosum peel extracts

The hydroxyl and nitric oxide, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities and total phenolic content of  Solanum tuberosum peels extracts in ethyl acetate and methanol were investigated in vitro. Total Polyphenolic Contents were determined in terms of Gallic Acid Equivalent. Reducing power Assay was also determined by standard method. In the present study it has been demonstrated that, ethyl acetate extract contains higher amount of Polyphenolic Contents as compared to methanolic extract as well as DPPH Radical Scavenging is concentration dependent and Solanum tuberosum peel extract in ethyl acetate extract shows more DPPH Radical Scavenging than methanol extract. To conclude, Solanum tuberosum peels extracts showed a good antioxidant activity and might be an alternate to synthetic antioxidants available in the market.



Effects of nuclear breakup on 6Li+64Zn fusion reaction around barrier energies

We have studied the effect of breakup of weakly bound projectile on fusion reactions involving intermediate mass target within the framework of dynamic polarization potential approach. The sub barrier enhancement and the above barrier suppression have been found which significantly improves the matching between the fusion excitation function data and calculations for 6Li+64Zn system.



Chemo-enzymatic conversion of biomass into bio-ethanol

The energy crisis and environmental pollution from use of fossil fuels have become more serious globally which insisted us to explore the use of bio-fuels as cheaper and cleaner alternatives to fossil fuels. The higher production costs of alcohol, however, are an obstacle to the production of this energy source. Selection of biomass with higher yields and higher sugar content and at lower cost is, therefore, essential to cut down costs of ethanol production. In the present research we have taken fruit peels (orange and banana) as a substrate for the production of ethanol by some chemo-biological methods. Saccharomyces cerevisiae was taken for the fermentation and then the distillation we could recover 10-11% ethanol concentration. It has various advantages over the traditional fuel. It is biodegradable, low in toxicity and causes little environmental pollution if spilt. Bio-ethanol has higher octane number, broader flammability limit, higher flame speed and higher heat of vaporization than gasoline. It is much cleaner and releases no toxic gases.



Journal information submitted by: Dr. Bhupender Singh

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